Clenbuterol

Package leaflet (information for patients)

Tradename
Clenbuterol

Dosage form
Tablets 40 mcg.

Description
Round, flat, beveled to the edge white tablets with an imprint in the form of the brand name "V" on one side.

Structure
Active ingredient: Clenbuterol 40 mcg.
Excipients: microcrystalline cellulose 102, calcium stearate, aerosil ® 200 (hydrophilic pyrogenic silicon dioxide).

Pharmacotherapeutic group
Means for the treatment of obstructive airways diseases, Beta2-selective adrenergic agonist.

Pharmacological properties
Clenbuterol is a stimulant (32-adrenergic receptors. It has a bronchodilator and secretolytic effect. It excites p2-adrenergic receptors, stimulates adenylate cyclase, increases the content of cAMP in cells, which, by affecting the protein kinase system, deprives myosin of the ability to bind with actin and promotes bronchial relaxation.
Pg-adrenergic receptor stimulants can cause positive chronotropic and inotropic effects (increased heart rate and strength).
It inhibits the release of mediators from mast cells that contribute to bronchospasm and inflammation of the bronchi. Reduces edema or congestion in the bronchi, improves mucociliary clearance.
The action begins 10-15 minutes after taking the drug inside and reaches a maximum after 2-3 hours.
Pharmacokinetics
After oral administration, it is rapidly and completely absorbed in the digestive tract. Tsh in plasma - about 3 hours. High plasma concentrations are created 15 minutes after a single dose and are observed within 7-24 hours after a single dose. Biotransformed in the liver and with the formation of 8 metabolites.
It is excreted mainly in the urine (about 78% unchanged). A small part is excreted in the bile.

Indications for use
Symptomatic treatment of bronchial asthma and chronic respiratory diseases.
Clenbuterol is not intended to relieve an attack of bronchial asthma.
Clenbuterol for bronchial asthma should be prescribed as an additional drug against the background of anti-inflammatory therapy with corticosteroids or other drugs that affect the inflammatory process.

Method of administration and dosage
Inside, carrying out long-term treatment in adults and children over 12 years of age is prescribed in a dose of 10-20 mcg 2 times a day, if necessary, it is possible to increase the dose to 8 mcg / day (until the condition improves). The daily dose for children (for 2 doses): from 6 to 12 years old - 15 μg, 4-6 years old - 10 μg, 2-4 years old (body weight 12-16 kg) - 7.5 μg, 8-24 months (body weight 8-12 kg) - 5 μg, up to 8 months (body weight 4-8 kg) - 2.5 μg.

Side effects
From the side of the cardiovascular system: tachycardia, extrasystole, arterial hypo - or (more often) hypertension, cardialgia, facial hyperemia.
From the side of the central nervous system: tremor of the fingers, anxiety, headache, dizziness, general weakness, insomnia, paresthesia.
From the digestive system: dry mouth, nausea, vomiting, gastralgia. Allergic reactions: skin rash, urticaria, bronchospasm, angioedema.
Others: increased sweating, hypokalemia, muscle cramps.

Contraindication
• an acute period of myocardial infarction;
• thyrotoxicosis (thyroid disease);
• aortic stenosis;
• ischemic heart disease;
• tachycardia, tachyarrhythmia ;
• Hypertrophic I obstructive cardiomyopathy ;
• pregnancy (first trimester and just before childbirth);
• lactation;
• hypersensitivity to clenbuterol and other components of the drug.
Due to the content of sorbitol, the drug is contraindicated in a patient with fructose intolerance.

Overdose
Symptoms: arrhythmia, tachycardia, hypertension, false angina, tremor, the possibility of development is, hypokalemia and hyperglycemia.
Treatment: gastric lavage, appointment of activated carbon, the use -salt solutions, control the level of potassium in blood serum, symptomatic therapy.

Precautions
When treating patients with diabetes mellitus, it is necessary to periodically monitor the level of glucose in the blood. The use of clenbuterol can lead to an increase in body weight due to the presence of an anabolic effect, and when administered to athletes, clenbuterol can cause a positive result during doping control.
During treatment with clenbuterol, resistance and rebound syndrome may develop.
Influence on the ability to drive vehicles and mechanisms
Due to the possibility of tremor, dizziness and weakness, during treatment with clenbuterol, it is necessary to refrain from performing potentially hazardous activities that require special attention and quick reactions (driving and other vehicles, working with moving mechanisms).

Interaction with other medicinal products
Beta-blockers are pharmacological antagonists of clenbuterol and can reverse its action.
Clenbuterol reduces the effect of hypoglycemic agents. Increases the risk of developing intracardiac conduction disorders while prescribing with MAO inhibitors and theophylline. Increases the toxicity of cardiac glycosides and increases the risk of arrhythmias. In combination with sympathomimetic agents, there is a mutual increase in toxicity.
Clenbuterol reduces the effect of hypoglycemic drugs.
Clenbuterol reduces the effectiveness of antihypertensive drugs.
The effect of clenbuterol is potentiated by tricyclic antidepressants, beta- adrenomimetics and anticholinergics.
Halothane and other halogenated hydrocarbon anesthetics, as well as cyclopropane, may potentiate the proarrhythmogenic effect of clenbuterol.

Special instructions
With extreme caution, the drug should be prescribed for hyperthyroidism, diseases of the cardiovascular system (arrhythmias, heart defects, coronary artery disease, severe arterial hypertension, cardiomas andopathies), diabetes mellitus.
With a sharp withdrawal of the drug, the development of the "rebound" syndrome is possible.
In patients with poorly controlled diabetes mellitus, Clenbuterol-Pharma pheochromocytoma, the syrup can be used only under medical supervision. It is necessary to use the drug with caution in patients with glaucoma and prostatic hypertrophy.

Pregnancy and elbowing
The drug should not be prescribed during pregnancy, especially in the first trimester, in the prenatal period and during childbirth, because Clenbuterol, when used in high doses, has a tocolytic effect.
In preclinical studies, it has been shown that clenbuterol passes into breast milk. For women during breastfeeding, taking Clenbuterol-Pharma, syrup is contraindicated.

Influence on the ability to drive vehicles and work with mechanisms
Due to the possibility of tremor, dizziness and weakness during the period of taking the drug, it is necessary to refrain from engaging in potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Storage conditions
Store in a dry, dark place at a temperature not exceeding 25 ° C, out of the reach of children.

Shelf life
3 years. Do not use after the expiration date printed on the package.

Vacation conditions
On prescription.

Packaging
Clenbuterol 40 mсg Tablets. There are 25 tablets in a blister. 4 blisters are packed in a cardboard box together with an enclosed leaflet.